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Approved GLP-RAs In 2005, Exendin-4 (Exenatide/ BYETTA), the world's first GLP-1RA, was approved by the FDA for the adjuvant treatment of type 2 diabetes with two injections per day (BID)
They want to make sure the treatment is safe and effective
They exert their antitumor effects through multiple mechanisms, including epigenetic modification, inhibition of key signaling pathways, and modulation of the tumor microenvironment ( Figure 3 )
Oct 7 2022;79(11):543
Most participants experience minimal weight loss during the first month
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